Diagnosis and treatment
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Head of clinic Blog

Peptic Ulcer

Peptic Ulcer
£Figure1

It is generally speculated that peptic ulcer (gastric or duodenal ulcer) is associated with hereditary predisposition and environmental factors complicated by various local factors. The representative etiologies of ulcer include circulatory disorder and inflammation. However, the concept that peptic ulcer is caused by inflammation has recently been accepted. This is because Helicobacter Pylori described in the section, Gastric Cancer, has frequently been detected in patients with ulcer. In other words, it has been reported that this pathogen causes gastritis, reducing the cytoprotection of the digestive tract mucosa, facilitating ulcer development. Furthermore, it has been indicated that eradication treatment significantly decreases the recurrence rate of ulcers.

Of course, ulcer development is not associated with Helicobacter Pylori infection in the digestive tract mucosa only. However, peptic ulcer is also an infection in some respects. In Japan, it is reported that the detection rates of this pathogen are approximately 80% in patients with gastric ulcer and 90% in those with duodenal ulcer, suggesting the involvement of this pathogen especially in the duodenum.

The figure1 was taken in a patient with recurrent duodenal ulcer. Eradication treatment is required in such a case of refractory or recurrent ulcer.